The reaction is usually accompanied by the ejection of one or more neutrons.
In 1934 Enrico Fermi proposed a theory that explained the three forms of beta decay.
The synthesis of a mole of helium releases 3.4 million times as much energy.
Since most nuclear reactions are carried out on very small samples of material, the mole is not a reasonable basis of measurement.
The binding energy can also be viewed as the amount of energy it would take to rip the nucleus apart to form isolated neutrons and protons.